Sen. R.C. Soles said in a statement Wednesday he won't seek a 22nd consecutive term. He was first elected to the General Assembly in 1968.
"I want to thank my colleagues, friends, and constituents for their support through the years. It has been an honor to serve and I will always be grateful for the privilege," read the statement.
State prosecutors announced this month they plan to seek an assault charge against Soles after a grand jury found probable cause he acted criminally when he shot a former law client.
Soles made no reference to the case in his statement.
Soles is the latest powerful Democrat leaving the Senate.
Outgoing Majority Leader Tony Rand is to resign Thursday to head the parole commission. Finance Committee co-chairman David Hoyle also won't seek re-election.