When they arrived on scene, they found a two-story house with fire showing.
Crews from the Wendell, Hopkins, and Corinth-Holders fire departments were called in to assist.
Firefighters spent much of the night extinguishing the blaze, and dousing hot spots.
Investigators say the fire likely started in a back laundy room or deck area of the house, but because it was vacant, they are looking into whether the fire may be suspicious.
No one was hurt.