The accident occurred near the intersection of Rock Quarry Road and Ruby Street.
Five people are at Wake Med hospital including a sheriff's deputy. The status of the injuries is unavailable at this time.
The incident began with a report of a carjacking in Knightdale which lead to a police chase.
A deputy attempted to block the intersection involving the carjacking.
A Wake County Sheriff's vehicle and two other automobiles were involved in the collision.
Two suspects are in custody, a manhunt is underway for a third suspect.
Knightdale officers are investigating the carjacking; Highway Patrol is investigating the accident and Wake County officials is investigating the police chase.
Chopper 11 is on the scene. Stay with Eyewitness News for updates.