Officers say the thieves cut phone lines and security systems to break-in. The rear door locks were also broken.
The doctors who own the practices were shocked by the thieves' brazenness.
"They obviously were looking for drugs and we don't keep drugs in the office - they took about 100 dollars petty cash and rifled through all the drawers - but they really didn't do too much damage," Western Wake Surgical Dr. Eric Duberman said.
Items were thrown everywhere inside of the three medical offices. A safe was also drilled open to gain access to valuables and potent drugs.
Cary police were on the scene Sunday afternoon dusting for fingerprints and looking for any clues in the case.
Doctor Robert Ferall is the co-owner Western Wake Pediatrics, another office hit by the thieves.
He says there was some damage to the practice – but is worried more about medical records.
"Fortunately there were no breaches there, which was our main concern," Dr. Ferall said.
The narcotics were taken from a third office in the complex. The other practice hit was Cary Adult Medicine.
Locksmiths and security companies were on site Sunday repairing the damage.
The practices in the Parkway Professionals Complex tell ABC11 services will not be affected.
"Went through a lot of trouble for not much gain to disable all the security systems and put themselves at tremendous risk - most doctors don't keep a lot of medications in the office these days and you would think they would know that," Dr. Duberman said.