Officers were called to 134 Mill Dam Lane around 9:50 p.m. Saturday.
They found 46-year-old Edward Lee Brewington lying on the floor of a home with gunshot wounds.
He was taken to Wayne Memorial Hospital and later transferred to Pitt Memorial Hospital in Greenville for treatment.
He died at 12:24 a.m. Monday morning.
Anyone with information about the shooting is asked to call the Wayne County Sheriff's Office at (919) 731-1481 or Wayne County Crimestoppers at (919) 735-2255.