Officials said an anonymous tip led them to the home at 3950 Hickory Crossings Road.
Gary Scott, 28, was arrested on drug related charges including maintaining a dwelling to keep a controlled substance.
Two children were living at the address with Scott, though only one was home at the time of the arrest, according to police.
Authorities said the 3-year-old and 8-year-old may need to be decontaminated as a precaution.
This was Johnston County's 15th meth lab bust this year.
With information from Mickey Lamm/WTSB Radio