Crystal Mangum is charged with stabbing her boyfriend, Reginald Daye, with a kitchen knife during an argument in April 2011. Daye died 10 days later. Mangum claims it was all in self defense - and that a medical error is blamed for Daye's death.
On Friday, a judge allowed Mangum most recent attorney, Scott Holmes, to withdraw from her case after he cited conflict of interest earlier this week.
Mangum has gone through two other attorneys - who both asked to be removed from the case - and even represented herself for a time.
The revolving door of defenders has pushed back her trial date for years. She is charged with first-degree murder, assault with a deadly weapon, and larceny.
Mangum made national headlines in 2006 when she accused a group of Duke University lacrosse players of sexually assaulting her while she worked as a stripper at a party. The accusations were later found to be false, and Attorney General Roy Cooper dismissed all charges filed against the students.