The latest robbery happened around 10 a.m. Thursday at the BB&T branch in the 1100 block of West N.C. Highway 54, near Hope Valley Commons.
Jordan High School was placed on lockdown briefly as a precaution while officers searched for the suspect who fled from the bank on foot.
Police are looking for an African American man in 50's, who was described as standing between 5 feet 8 inches tall and 5 feet 9 inches tall and had facial hair. He was last seen wearing a puffy blue jacket, and blue, white, and yellow pajama pants.
Anyone with information about the suspect is asked to call Durham Police.
Meanwhile, authorities say three robberies happened Wednesday. One at the PNC Bank on Rogers Road in wake Forest, then another at a Yadkin Bank on Carver Street in Durham, and the third happened at the First South Bank on Executive Place in Fayetteville.
ABC11 asked the North Carolina Bankers Association if headed to the bank is safe nowadays and if bank robberies are on the rise.
"If you watch the news, you'd think there would be an uptick in bank robberies and actually since 2003 we've been trending steadily down," said Nathan Batts, with the N.C. Bankers Association, "and even this year, we may be on record as having the lowest number."
Next week, the Bankers Association will have a news conference with the FBI talking about the latest statistics.