It happened around 2:20 p.m. Tuesday in the 2600 block of East Shoreham Street.
Police say 28-year-old Desmond Ramario Williams was shot and killed. Neighbors told ABC11 that his body was lying in the middle of the road.
There were reports that a black vehicle was seen fleeing the scene after the shooting.
Anyone with information is asked to call Investigator A. Richards at (919) 560-4440, ext. 29337 or CrimeStoppers at (919) 683-1200.