The North Carolina Highway Patrol said a vehicle crashed just before 9 a.m. along St. Mary's Road, between Hardscrabble Drive and Red Pine Road.
Authorities identified the dead driver as 22-year-old Miguel Alejandro Rodriguez -Galvan of Hillsborough.
St. Mary's Road, along with other secondary roads in Durham, was considered "clear with some icy spots," according to authorities.
While troopers said ice was to blame, it was unclear if speed was also a factor.
The NCHP is still investigating the accident.
North Carolina Department of Transportation crews have since treated the roadway with a layer of salt and sand.