The call came in just after 9 a.m., according to police.
Upon arrival, officers found 31-year-old David Kelly dead inside of the Quality Inn in the 3700 block of Hillsborough Road.
Officials said the homicide happened during an altercation.
The investigation is ongoing.
Police are working to determine if a crash on Hillsborough Road and 9th Street is related to the incident.
This is a developing story. Check back for updates.
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Anyone with information is asked to call Investigator J. Mitchell at (919) 560-4440, ext. 29335 or CrimeStoppers at (919) 683-1200. CrimeStoppers pays cash rewards for information leading to arrests in felony cases and callers never have to identify themselves.