Rodolfo Padilla, 45, and 38-year-old Ovidio Cabrera of Hillsborough are charged with murder.
Authorities arrested both men Wednesday night.
The men are accused of the January 18 shooting of 48-year-old Delores Gomez in the Lakewood community. After the shooting, Gomez managed to get into his car and drive two block before crashing into a wooded area.
Police say all three of the men were acquaintances and believe robbery was the motive.