Deputies had to step between the two sides after some yelling and shoving broke out.
The families were in the building for a first court appearance scheduled for 29-year-old Kenya Domon Mangum, but the hearing was cancelled when he was indicted by a grand jury on a murder charge.
Police say Mangum stabbed his wife several times around 8 p.m. Sunday in the parking lot of a KFC/Taco Bell on South Miami Boulevard.
Twenty-three-year-old Amanda Mangum was taken to Duke University Hospital where she later died.
After the stabbing, an Amber Alert was issued for three of Amanda Mangum's children, an 8-year-old girl, 4-year-old boy, and a 2-year-old girl, who were believed to be with Kenya Mangum.
Shortly before 5 a.m. Monday, the children were found unharmed inside an apartment on Thames Avenue.
According to court records, Amanda had tried to leave her husband in 2007. She filed a restraining order saying Kenya choked her, kneed her in the stomach, and then threatened to kill her and promised to buy a gun.
The protective order was dismissed, most likely because Amanda dropped the charges or didn't show up in court to testify against her husband, according to court officials.
Her family told ABC11 Tuesday that friends had recently tried to get her to leave the relationship.
"Her friends tried to get her to go to a woman's shelter, but she wouldn't go," said Amanda's brother Robert Magruder.
"I didn't think it would escalate to this," said Amanda's friend Wendy Rigsbee. "When you're a woman in fear with four children it's hard."
Kenya Mangum has a past criminal record. He was charged with drug possession in Durham and a statutory sexual offense in Maine in 2002.
Amanda Mangum's children are now with relatives. Her family says it does not have the money for funeral expenses. It's in the process of setting up a bank account to take public donations.