Of about 200 potential jurors, 48 were excused by U.S. District Judge Catherine C. Eagles.
The remaining potential jurors will be called back Tuesday for individual questioning by attorneys.
Also in court Monday, we learned a deal has been worked out that will allow the accountant for former Edwards aide Andrew Young to testify.
Edwards faces six counts related to nearly $1 million in secret payments from two campaign donors used to help hide the married presidential candidate's pregnant mistress as he sought the White House.
Edwards mistress Rielle Hunter is on the witness list, as is the former candidate's eldest daughter, Cate Edwards.
As expected, Young is listed as a prosecution witness. Young handled the money for Hunter's care and falsely claimed paternity of Edwards' child. After repeatedly denying the affair, the former U.S. senator admitted the baby was his in 2010.
Key to the government's case is proving that Edwards, 58, knew about the payments, which prosecutors contend were illegal campaign donations under federal law.
The money came from Edwards' national campaign finance chairman, the late Texas lawyer Fred Baron, and campaign donor Rachel "Bunny" Mellon, an heiress and socialite who is now 101 years old. Both had already given Edwards' campaign the maximum $2,300 individual contribution allowed by federal law.
Baron's widow, Lisa Blue, is listed as a witness. Mellon is considered too frail to travel to the North Carolina courthouse from her Virginia estate, but her longtime lawyer, Alex Forger, is expected to testify.
Also on the witness list are two former members of the Edwards defense team, lawyers Wade Smith and Jim Cooney. Smith was forced to withdraw in in October after prosecutors suggested he had a conflict of interest. They said he might be called to testify about a 2009 conversation he had with Forger about Edwards' knowledge of the money from Mellon.
Former Edwards press secretary Jennifer Palmieri is expected to testify she was present in an Iowa hotel room in October 2007 when wife Elizabeth Edwards confronted the candidate, Baron and Baron's wife about the couple's support of Hunter.
According to Palmieri's account, Baron and Blue tried to calm Edwards' angry wife by saying the mistress was a "loose cannon" who had to be kept happy, lest she go to the press.
Eileen Mancera, a financial adviser to the Edwards campaign, is expected to testify that Baron called her in early January 2008 to chastise her for offering her services to the Obama campaign. Baron urged Mancera to stick with Edwards in the hope he would be named the Democratic vice-presidential nominee, according to the government.
Edwards dropped out of the presidential race on Jan. 30, 2008. It has not yet been decided whether he will testify in his own defense.
But if the former candidate does take the witness stand, the case could hinge on which admitted liar the jury chooses to believe -- Edwards, who appeared on national television to deny having an affair with Hunter and fathering her child, or Young, who claimed in a written statement that the baby was his.
If convicted, Edwards faces a maximum penalty of 30 years in prison and as much as $1.5 million in fines.