It happened around 10 a.m. in the 5000 block of Old Fairground Road.
Troopers said 22-year-old Samantha Jayne Bonventre ran off the roadway and struck a tree with her car. She died as a result of her injuries.
A passenger, 23-year-old James Theodore Murphy, was injured and transported to WakeMed. The extent of his injuries is unknown.