The accident happened just before 11 a.m. on I-40 just before the I-440 split at exit 301 near Rock Quarry Road in southeast Raleigh.
The wreck report from Raleigh Police showed the driver of the box truck, 42-year-old Alan George, of Statesville, clipped the back corner of a pick-up truck, driven by 53-year-old George Bright, causing both vehicles to overturn.
Diesel fuel leaked from the rental truck after it flipped on its side.
Both drivers were taken to WakeMed. Bright was treated and released and George was last listed in good condition.
The accident backed up traffic for hours. Lanes were finally reopened after noon.
Police said alcohol is believed to be a factor in the crash.