The man, who was armed with a knife, held police at bay for about three hours near Elk Road.
The incident started around 7:45 a.m. when family members reported the man missing.
Shortly after 8 a.m., police spotted his vehicle on Highway 301 and attempted to stop him.
The man ended up colliding with several vehicles on the highway, including an 18-wheeler. He then barricaded himself inside his vehicle as officers tried to get him to surrender.
Two hours later, negotiators saw the man began to cut his neck and decided to release pepper spray near his pick-up. He later turned himself in.
"Our intent all morning long was to use less lethal means to deal with this individual because we are here to help him not hurt him," Fayetteville Police Chief Harold Medlock said.
His name and further details have not been released at this time.
Highway 301 was reopened after 11 a.m.