It happened around 7:30 a.m. at the intersection of Holloway Street/Highway 98 at Chandler Road.
ABC11 has learned there were about 10 children on board the school bus at the time of the crash, but they were not injured.
However, the driver of one the cars was reportedly injured. It is unclear if anyone else was injured.
It is also unclear what caused the accident.
Holloway Street at Chandler Road is closed as authorities work to clear the scene.