The crash happened around 4 a.m. Saturday in the eastbound lanes of Interstate 440 between New Bern Avenue and U.S. Route 264.
Hunter Howell is facing a number of charges, including driving while impaired, for his involvement in accident that sent three people to WakeMed.
Shelby J. Wallace was in critical condition and Marvin Pendergraph was in serious condition as of 11 p.m. Saturday.
Howell is currently being held at the Wake County Detention Center.
This is the second serious accident in less than a week on I-440 near New Bern Avenue, and some drivers told ABC11 they are concerned about their safety when traveling on the beltline, especially when its dark out. They said the road is too dark and people drive high above the speed limit.
"It's just ridiculous. I think they need to fix the highways and get everything under control out there...A lot of people can't see. A lot of people driving crazy these days," said Raleigh resident DeeDee Boylorn.
"They tend to speed in that area," added Raleigh resident Jerry Freedman.
Early Sunday morning a man was accused of driving in the wrong direction and slamming into another car on I-440. Police believe he was driving while impaired.
Elizabeth Camille Bullock, 20, was killed instantly after being hit head-on. The man accused of driving in the wrong direction was sent to WakeMed but later died of his injures.
"We're thinking about writing to someone and trying to get more lighting out there in that area of the highway because at night it's very dark," said Bullock's friend Taylor Thomas.
Her friends are hoping something will change along the accident-prone section of I-440.
"I just feel like they should be doing more to prevent this kind of things from happening," said friend Cam Manning.